Resuscitation and Critical Care | Resource

Ventilator Optimizer

Lung Protection:
  • Tier 1 Tidal Volume (4–8 mL/kg • PBW)
  • Tier 2 Plateau Pressure (Pplat ≤ 30 cmH₂O)
  • Tier 3 Driving Pressure (ΔP ≤ 15 cmH₂O), ΔP = Pplat - PEEP
Physiological Drivers:
VENTILATION: Ve = RR x VT [Minute Ventilation (Ve)]
OXYGENATION: O2 = Paw x FiO2 [Alveolar Recruitment]
Fick’s Law | Gas Diffusion:
Gas Diffusion Rate =
Surface Area x Diffusion Gradient
Membrane Thickness
  • PEEP ➔ Surface Area | FiO₂ ➔ Diffusion Gradient
  • Membrane Disease State Constraints (e.g., Inflammation, infection, fibrosis)

1. Lung Protective Tidal Volume

Predicted Body Weight (PBW) -- kg
Tidal Volume (mL)
4 mL/kg
--
5 mL/kg
--
6 mL/kg
--
7 mL/kg
--
8 mL/kg
--

2. Target Rate Optimizer

New Respiratory Rate -- bpm
⚠️ WARNING: Monitor closely for Auto-PEEP and breath stacking configurations. Exercise extreme caution in severe obstructive lung disease paths (e.g., Asthma/COPD exacerbations) where preserving adequate Expiratory Time (E-time) remains completely mission-critical.

3. ARDSnet PEEP/FiO2 Titration Grid

FiO₂ 0.30.40.40.50.50.60.70.70.80.90.90.91.0
PEEP 5588101010121414161820-24
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